Kinetically
hot residues
Critically important for the overall stability of the molecule
a.
Side view of the close neighborhood of the fusion peptide (HA2
residues 1-20, shown in pink) in one subunit of HA.
b.
Cross-sectional top view of the same region.The
HA2 residues (Asp112, Met115, Tyr22 and Ala44) distinguished in
the fast modes
that wrap across the fusion peptide colored red.
We
compared these peaks with the conserved residues identified by the
multiple alignment of 78 sequences.
Top
and bottom panels of the graph shows the distribution fluctuation
of HA1 and HA2, respectively.
Notably,
out of the 14 residues of HA1 distinguished as the strongest peaks
in the fast mode shapes, 10 coincide with the fully or highly
conserved residues.
In
the case of HA2 monomers, all of the peaks lie within the set of
conserved residues identified by multiple alignments.
University of Pittsburgh ---------- School of Medicine
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Critically important for the overall stability of the molecule
