The
anisotropic network model (ANM) is the extension of the GNM to the
3N-d space of collective modes.
The
inter-residue ‘distances’ are controlled by harmonic
potentials in the GNM, ANM adopts the further assumption that the
three (-x, -y and -z) components of the inter-residue separation
vectors obey Gaussian dynamics.
ANM
thus involves the inversion of a 3N x 3N Hessian matrix H
that replaces the N x N Kirchhoff matrix G (Doruker et
al., 2000, Atilgan et al., 2001).
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