Functional Motions of Influenza Virus Hemagglutinin

Monomer
Native Form
(Neutral pH)

Low pH form

-Crucial to HA mediated membrane fusion -highly conserved N-terminus of HA2    -lies in the trimer interface

(Wilson et al., 1981; Weis et al., 1990)
 

Folding of helix B at low pH

The free energy of the low pH form is lower than that of the neutral pH form, by 0.98 RT per residue. 

The contribution of the B-loop containing Glu57, Glu61, Glu67, Glu69, Glu72, Glu74 is 3.47RT per residue.

Return to Influenza Hemagglutinin Main Page

 

University of Pittsburgh ---------- School of Medicine
W1041 Biomedical Science Tower  200 Lothrop St., Pittsburgh, PA 15261.     Phone : (412) 648-3333,  Fax: (412) 648-3163

Tel : (412) 648-6671,  Fax: (412) 648-6676