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Dr. Srinath
Cheluvaraja
(412) 648-7775
Email |
Research Associate |
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Dr. Chakra
Chennubhotla
(412) 648-7785
Email |
Research Associate |
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Dr.
Edward Lyman
(412)
648-7767
Email |
Research Associate |
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Dr.
Shaun Mahony
(412) 648-8688
Email |
Research Associate |
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Dr.
Rajan Munshi
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Research Associate
My research involves analysis of gene expression data from oligonucleotide
DNA microarray experiments. Expression profiles from five regions of
the rat brain were obtained in the absence and presence of cocaine
by hybridization on commercially available microarrays from
Affymetrix, Inc. Using clustering techniques, our goals are (i) to
determine if cocaine treatment affects a particular region of the
brain, and (ii) to identify a set of genes that are regulated in
response to cocaine."
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Dr. Indira Shrivastava
(412-648-7767)
Email |
Research Associate
Membrane proteins transport ions
and/or solutes across the membrane and are capable of making
transitions between conducting and non-conducting conformations.
At the theoretical level,
molecular dynamic simulations serve as an investigative
tool to understand the functioning of the membrane proteins at the
molecular level, but are limited to accessing only local
conformational changes. The
Gaussian Network Model (GNM) explores the large-scale
conformational changes which occur over a longer time scale and are
more global, in their properties. Thus, with a judicious
combination of MD simulations
and GNM , I hope to
be able to predict local and global structural changes associated
with the transport mechanisms of membrane proteins.
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Dr. Dror Tobi
(412)
648-7785
Email |
Research Associate |
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Dr. Ron White
(412) 648-7775
Email |
Research Associate |
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Dr. Lee-Wei
Yang
(412) 383-5743
Email
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Research Associate
My research interest is to reveal the
structure-dyanmics-function relationship. Simplified elastic
network models are used as means to identify the common dynamic
pattern using a large set of nonhomologous enzymes and utilize the
found common pattern as a feature to improve the prediction of the
location of active site in enzymes. The current challenge is to
characterize the common dynamic pattern contributed by proteins of
different folds in a given enzyme family. I'm also interested in
constructing biological databases and creating web-based dynamics
calculation tools.
For a detailed research description please
click here.
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Dr. Marty
Ytreberg
(412) 648-7767
Email |
Research Associate
I'm interested in developing
rigorous, fast methods for calculating free energy differences (i.e.
binding affinities) based upon Jarzynski's relation. The goal is to
be able to reliably and rigorously estimate free energy differences
with as few work values as possible. I'm also interested in
developing algorithms that are capable of helping us understand large
conformational changes and binding/unbinding events in proteins.
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